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In 1988, Janeway, an immunologist, founded the Section of Immunobiology at the Yale University School of Medicine. He also wrote the classic text on the subject, Immunobiology: The Immune System in Health and Disease, which is still in use. Janeway studied "innate immunity", the body's natural defense against infection, and how "T cells" ward off disease. Dr. Janeway died April 12 from cancer. He was 60. From This is True for 13 April 2003 Suggestions for further reading:
 By: Kenneth Murphy List Price: $95.95 Amazon Price: $95.95 Editorial Review: Janeway's Immunobiology, Seventh Edition is an introductory text for use in immunology courses for undergraduates, graduate students and medical students. It guides the reader through the immune system in all its aspects - from the first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. The Seventh Edition has been comprehensively updated throughout, and includes new information on topics such as NK cells, Toll-like receptors, AID, viral evasins, mucosal immunity, and celiac disease, to name a few. Each copy of the book includes a revised CD-ROM, Immunobiology Interactive, which contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes. Janeway's Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, full-color art program, scientific accuracy and consistent viewpoint - that of the host's interaction with an environment containing many species of potentially harmful microorganisms.  List Price: $159.00 Amazon Price: $116.07 Editorial Review: Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV.
 List Price: $129.00 Amazon Price: $104.49 Editorial Review: Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.  List Price: $349.00 Amazon Price: $349.00 Editorial Review: Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.  List Price: $174.95 Amazon Price: $174.95 Editorial Review: T Lymphocytes in the Liver is the first book to offer a comprehensive review of the newly understood relationship between the liver and the immune system. This edited volume examines the immunobiology of T cells - the way their behavior in the liver differs from that in other organs, and, conversely, the liver's ability to effect changes in the activity of such immune cells. A number of relevant, cutting-edge issues are considered, including vaccine development, the liver's potential role in autoimmune tissue damage, tolerance and transplant rejection, and the use of animal organs for human patients. Contributing authors from diverse specialties discuss topics including: * T cells expressing antigen receptors in the liver * Active T cells in the liver * Extrathymic T cells in the liver * The induction of peripheral tolerance by portal vein administration of antigen * The immunobiology of viral hepatitis * Immunity to Listeria monocytogenes infection of the liver * Malaria and the liver * T cells and autoimmune liver disease * Hepatic T cells in primary sclerosing cholangitis and autoimmune hepatitis |
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