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A chemist and pharmacologist, in the 1940s Axelrod was asked to figure out why a popular headache remedy caused terrible side effects in some users. He not only isolated the problem, he determined which ingredient was effective for treating headaches: acetaminophen (also known as paracetamol), now the active ingredient in Tylenol. He also studied how the liver metabolized drugs, and discovered the hormone melatonin. But he's best known for his work on a team of scientists who studied how neurotransmitters -- brain chemicals -- worked to affect mood, leading directly to refined anti-depressant drugs called selective serotonin re-uptake inhibitors (such as Prozac, Zoloft and Paxil); he shared a Nobel Prize for Medicine for the work. "His contributions to pharmacology, especially in terms of how drugs act in the brain, were extraordinary," says Dr. Solomon Snyder, director of the neuroscience department at the Johns Hopkins University School of Medicine. "In fact, the work for which he got the Nobel Prize was just a tiny percentage of his scientific output." Dr. Axelrod died at home December 29. He was 92. From This is True for 26 December 2004 Suggestions for further reading:
 By: Daniel G. Amen List Price: $15.00 Amazon Price: $9.00 Editorial Review: BRAIN PRESCRIPTIONS THAT REALLY WORK In this breakthrough bestseller, you'll see scientific evidence that your anxiety, depression, anger, obsessiveness, or impulsiveness could be related to how specific structures in your brain work. You're not stuck with the brain you're born with. Here are just a few of neuropsychiatrist Dr. Daniel Amen's surprising--and effective--"brain prescriptions" that can help heal your brain and change your life: To Quell Anxiety and Panic: ¸ Use simple breathing techniques to immediately calm inner turmoil To Fight Depression: ¸ Learn how to kill ANTs (automatic negative thoughts) To Curb Anger: ¸ Follow the Amen anti-anger diet and learn the nutrients that calm rage To Conquer Impulsiveness and Learn to Focus: ¸ Develop total focus with the "One-Page Miracle" To Stop Obsessive Worrying: ¸ Follow the "get unstuck" writing exercise and learn other problem-solving exercisesIn this age of do-it-yourself health care (heck, if the doctor only sees you for 10 minutes each visit, what other options are there?), Change Your Brain, Change Your Life fits in perfectly. Filled with "brain prescriptions" (among them cognitive exercises and nutritional advice) that are geared toward readers who've experienced anxiety, depression, impulsiveness, excessive anger or worry, and obsessive behavior, Change Your Brain, Change Your Life milks the mind-body connection for all it's worth. Written by a psychiatrist and neuroscientist who has also authored a book on attention deficit disorder, Change Your Brain contains dozens of brain scans of patients with various neurological problems, from caffeine, nicotine, and heroin addiction to manic-depression to epilepsy. These scans, often showing large gaps in neurological activity or areas of extreme overactivity, are downright frightening to look at, and Dr. Amen should know better than to resort to such scare tactics. But he should also be commended for advocating natural remedies, including deep breathing, guided imagery, meditation, self-hypnosis, and biofeedback for treating disorders that are so frequently dealt with by prescription only.  By: David D. Burns List Price: $7.99 Amazon Price: $7.99 Editorial Review: FEELING GOOD FEELS WONDERFUL The good news is that anxiety, guilt, pessimism, procrastination, low self-esteem, and other "black holes" of depression can be cured without drugs.In FEELING GOOD, eminent psychiatrist, David D. Burns, M.D., outlines the remarkable, scientifically proven techniques that will immediately lift your spirits and help you develop a positive outlook on life. Now, in this updated edition, Dr. Burns adds an ALL-NEW CONSUMER'S GUIDE TO ANTIDEPRESSANT DRUGS as well as a new introduction to help answer your questions about the many options available for treating depression. - Recognize what causes your mood swings BEGIN NOW, TO EXPERIENCE THE JOY OF FEELING GOOD  By: Matthew McKayJeffrey C. WoodJeffrey Brantley List Price: $21.95 Amazon Price: $14.93 Editorial Review: A Clear and Effective Approach to Learning DBT Skills First developed for treating borderline personality disorder, dialectical behavior therapy (DBT) has proven effective as treatment for a range of other mental health problems, especially for those characterized by overwhelming emotions. Research shows that DBT can improve your ability to handle distress without losing control and acting destructively. In order to make use of these techniques, you need to build skills in four key areas--distress tolerance, mindfulness, emotion regulation, and interpersonal effectiveness. This book, a collaborative effort from three esteemed authors, offers straightforward, step-by-step exercises for learning these concepts and putting them to work for real and lasting change. Start by working on the introductory exercises and, after making progress, move on to the advanced-skills chapters. Whether you are a professional or a general reader, whether you use this book to support work done in therapy or as the basis for self-help, you'll benefit from this clear and practical guide to better managing your emotions. The individual struggling with overwhelming emotions and DBT therapists will benefit significantly from this workbook. McKay, Wood and Brantley have expanded and translated DBT Skills, making Linehan's iconic work on emotional skill building even more accessible and easy to apply to everyday life.  By: Kay Redfield Jamison List Price: $14.95 Amazon Price: $10.17 Editorial Review: As a founder of UCLA's Affective Disorder Clinic and a co-author of a standard medical text, Dr. Kay Redfield Jamison may be the foremost authority on manic-depressive illness. She is also one of its survivors. And it is this dual perspective -- as healer and healed -- that makes Jamison's memoir so lucid, learned, and profoundly affecting. Even as she was pursuing her psychiatric training, Jamison found herself succumbing to the exhilarating highs and paralyzing lows that afflicted many of her patients. Though the disorder brought her seemingly boundless energy and mercurial creativity, it also propelled her into spending sprees, episodes of violence, and an attempt at suicide. Powerfully candid, exceptionally wise, An Unquiet Mind is one of those rare books that has the power to transform lives -- and even save them.In Touched with Fire, Kay Redfield Jamison, a psychiatrist, turned a mirror on the creativity so often associated with mental illness. In this book she turns that mirror on herself. With breathtaking honesty she tells of her own manic depression, the bitter costs of her illness, and its paradoxical benefits: "There is a particular kind of pain, elation, loneliness and terror involved in this kind of madness.... It will never end, for madness carves its own reality." This is one of the best scientific autobiographies ever written, a combination of clarity, truth, and insight into human character. "We are all, as Byron put it, differently organized," Jamison writes. "We each move within the restraints of our temperament and live up only partially to its possibilities." Jamison's ability to live fully within her limitations is an inspiration to her fellow mortals, whatever our particular burdens may be. --Mary Ellen Curtin  By: David J. Miklowitz List Price: $19.95 Amazon Price: $13.57 Editorial Review: Thanks to sharper diagnosis and better medicine, the future is brighter for people with bipolar disorder than in past generations. But if you or someone you love is struggling with the frantic highs and crushing lows of this illness, there are still many hurdles to surmount at home, at work, and in daily life. *How can you learn to distinguish between the early warning signs of mood swings and the normal ups and downs of life? *What medications are available, and what are their side effects? *What should you do when you find yourself escalating into mania or descending into depression? *How can you get the help and support you need from family members and friends? *How can you tell your coworkers about your illness without endangering your career? In this comprehensive guide, Dr. David J. Miklowitz offers straight talk that can help you tackle these and related questions, take charge of your illness, and reclaim your life. A leading researcher and clinical specialist who knows what works, Dr. Miklowitz supplies proven tools to help you achieve balance--and free yourself from the emotional and financial havoc that result when symptoms rule your life--without sacrificing your right to rich and varied emotional experiences. This essential resource will help you and your family members come to terms with the diagnosis, recognize early warning signs of manic or depressive episodes, cope with triggers of mood swings, resolve medication problems, and learn to collaborate effectively with doctors and therapists. You'll learn specific ways to ask for support and help from your family and friends--and what to do when their "caring" feels like "controlling." For times when the going gets tough, a wealth of examples of how others have dealt with similar challenges offer new perspectives and new solutions. Whether you have recently been diagnosed with bipolar disorder, are considering seeking help for the first time, or have been in treatment for years, this empowering book is designed to help put you--not your illness--back in charge of your life. |
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